The following publications and presentations were generated from research efforts supported by the Center for Microbial Pathogenesis and Host Inflammatory Responses (CMPHIR).

Publications

Project Leaders

Insight into the Dual Functions of Bacterial Enhancer-Binding Protein Rrp2 of Borrelia burgdorferi. Yin Y, Yang Y, Xiang X, Wang Q, Yang ZN, Blevins J, Lou Y, Yang XF. J Bacteriol. 2016 Apr28;198(10):1543-52. doi: 10.1128/JB.01010-15. Print 2016 May 15. PubMed PMID: 26977110; PubMed Central PMCID: PMC4859600.

Complete Genome Sequences of Two Novel Isolates of Human Parainfluenza Virus 1 Associated with Acute Respiratory Infection. Denson JL, Kennedy JL, Dehority WN, Eickman MM, Schwalm KS, Stoner AN, Kincaid JC, Abramo TJ, Thompson TM, Ulloa EM, Burchiel SW, Young SA, Dinwiddie DL. Genome Announc. 2016 Oct 13;4(5). pii: e01154-16. doi: 10.1128/genomeA.01154-16. PubMed PMID: 27738046; PubMed Central PMCID: PMC5064119

Complete Genome Sequence of a Novel WU Polyomavirus Isolate from Arkansas, USA, Associated with Acute Respiratory Infection. Kennedy JL, Denson JL, Schwalm KS, Stoner AN, Kincaid JC, Abramo TJ, Thompson TM, Ulloa EM, Burchiel SW, Dinwiddie DL. Genome Announc. 2017 Jan 12;5(2). pii: e01452-16. doi: 10.1128/genomeA.01452-16. PubMed PMID: 28082496; PubMed Central PMCID: PMC5256223.

Aspirin-exacerbated respiratory disease: Prevalence, diagnosis, treatment, and considerations for the future. Kennedy JL, Stoner AN, Borish L. Am J Rhinol Allergy. 2016 Nov 1;30(6):407-413. doi: 10.2500/ajra.2016.30.4370. Review. PubMed PMID: 28124651; PubMed Central PMCID: PMC5108840.Li LX, Labuda JC, Imai DM, Griffey SM, McSorley SJ. CCR7 Deficiency Allows

CCR7 Deficiency Allows Accelerated Clearance of Chlamydia from the Female Reproductive Tract. Li LX, Labuda JC, Imai DM, Griffey SM, McSorley SJ. Journal of immunology (Baltimore, Md. : 1950). 2017 October 1;199(7):2547-2554. PubMed PMID: 28801359; PubMed Central PMCID: PMC5605455

An interaction domain in human SAMD9 is essential for myxoma virus host-range determinant M062 antagonism of host anti-viral function. Nounamo B, Li Y, O’Byrne P, Kearney AM, Khan A, Liu J. Virology. 2017; 503:94-102. NIHMSID: NIHMS848503 PubMed [journal] PMID: 28157624, PMCID: PMC5419587

Stress Beyond Translation: Poxviruses and More. Liem J, Liu J. Viruses. 2016; 8(6). PubMed [journal] PMID: 27314378, PMCID: PMC4926189

Pilot Project Leaders

Epithelial Cell Extrusion Zones Observed on Confocal Laser Endomicroscopy Correlates with Immunohistochemical Staining of Mucosal Biopsy Samples. Liu JJ, Kay TM, Davis EM, Lou Y, Kao D, Claggett B, Fedorak RN, Irvin RT. Dig Dis Sci 2016;61:1895-902. PMID: 2709841

Hijacking Host Cell Highways: Manipulation of the Host Actin Cytoskeleton by Obligate Intracellular Bacterial Pathogens. Colonne PM, Winchell CG, Voth DE. Frontiers in cellular and infection microbiology. 2016; 6:107. PubMed PMID: 27713866 PMCID: PMC5031698

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Voth DE, etc. Autophagy. 2016; 12(1):1-222. PubMed PMID: 26799652 PMCID: PMC4835977

Dining in: intracellular bacterial pathogen interplay with autophagy. Winchell CG, Steele S, Kawula T, Voth DE. Current opinion in microbiology. 2016; 29:9-14. NIHMSID: NIHMS727321 PubMed PMID: 26462048 PMCID: PMC4755823

Development of an Ex Vivo Tissue Platform To Study the Human Lung Response to Coxiella burnetii. Graham JG, Winchell CG, Kurten RC, Voth DE. Infection and immunity. 2016; 84(5):1438-45. PubMed PMID: 26902725 PMCID: PMC4862715

Vasodilator-Stimulated Phosphoprotein Activity Is Required for Coxiella burnetii Growth in Human Macrophages. Colonne PM, Winchell CG, Graham JG, Onyilagha FI, MacDonald LJ, Doeppler HR, Storz P, Kurten RC, Beare PA, Heinzen RA, Voth DE. PLoS pathogens. 2016; 12(10):e1005915. PubMed PMID: 27711191 PMCID: PMC5053435

PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis. Fujiwara T, Ye S, Castro-Gomes T, Winchell CG, Andrews NW, Voth DE, Varughese KI, Mackintosh SG, Feng Y, Pavlos N, Nakamura T, Manolagas SC, Zhao H.JCI insight. 2016; 1(17):e86330. PubMed PMID: 27777970 PMCID: PMC5070964

Additional CMPHIR-Related Investigators (by date)

Fujiwara T, Zhou J, Ye S, Zhao H. RNA-binding protein Musashi2 induced by RANKL is critical for osteoclast survival. Cell death & disease. 2016 July 21;7:e2300. PubMed PMID: 27441652; PubMed Central PMCID: PMC4973353

Jolly LA, Massoll N, Franco AT. Immune Suppression Mediated by Myeloid and Lymphoid Derived Immune Cells in the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by HrasG12V and Pten Loss. J Clin Cell Immunol. 2016 Oct;7(5). pii: 451. Epub 2016 Sep 16. PMID: 27942419 PMCID: PMC5145275

Ye S, Fujiwara T, Zhou J, Varughese KI, Zhao H. LIS1 Regulates Osteoclastogenesis through Modulation of M-SCF and RANKL Signaling Pathways and CDC42. International journal of biological sciences. 2016;12(12):1488-1499. PubMed PMID: 27994513; PubMed Central PMCID: PMC5166490

Sengupta D, Tackett AJ. Proteomic Findings in Melanoma. Journal of proteomics & bioinformatics. 2016 April;9(4). PubMed PMID: 27274624; PubMed Central PMCID: PMC4888906

Meeker DG, Jenkins SV, Miller EK, Beenken KE, Loughran AJ, Powless A, Muldoon TJ, Galanzha EI, Zharov VP, Smeltzer MS, Chen J. Synergistic Photothermal and Antibiotic Killing of Biofilm-Associated Staphylococcus aureus Using Targeted Antibiotic-Loaded Gold Nanoconstructs. ACS infectious diseases. 2016 April 8;2(4):241-250. PubMed PMID: 27441208; PubMed Central PMCID: PMC4945994

Hartman JH, Miller GP, Caro AA, Byrum SD, Orr LM, Mackintosh SG, Tackett AJ, MacMillan-Crow LA, Hallberg LM, Ameredes BT, Boysen G. 1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice. Toxicology. 2017 March 1;378:114-124. PubMed PMID: 28082109; PubMed Central PMCID: PMC5319481

Presentations and Posters

Blevins, J.S., 2016. Bacterial virulence with a ‘twist’: Using molecular genetics to study pathogenic Borrelia. Baylor College of Medicine, Department of Molecular Virology & Microbiology, Houston, TX.  Invited by Dr. Robert Ramigo, Waco, Texas.

Litteken, C., Latham, J.I., Ratliff, C.T., Fullerton, Lopez, J., and Blevins, J.S., 2017. Adaptive gene regulation in the relapsing fever spirochete, Borrelia turicatae. UAMS Student Research Symposium, Little Rock, Arkansas.

Brueggeman, E., Latham, J.I., Fullerton, M.P., and Blevins, J.S., 2016. Contribution of BadR and BosR to gene regulation in Borrelia turicatae. UAMS Summer Undergraduate Research Symposium, Little Rock, Arkansas.

Brueggeman, E., Latham, J.I., Fullerton, M.P., and Blevins, J.S., 2016.  Contribution of BadR and BosR to gene regulation in Borrelia turicatae. Central Arkansas Summer Undergraduate Research Symposium, Little Rock, Arkansas.

Latham, J.I., Podgorski, M., Wilder, H., Lopez, J., and Blevins, J.S., 2016. Studying the temperature-dependent gene response in the relapsing fever spirochete, Borrelia turicatae. International Conference on Relapsing Fever, Lake Arrowhead, California.

Stoner AN, Goudie A, Stern J, Kennedy JL. “Impact and Seasonality of Respiratory Viral Illnesses: A Retrospective Study.” J Allergy Clin Immun.  Feb 2017.  139(2): AB202. American Academy of Allergy, Asthma, and Immunology. Atlanta, Georgia.

Dinwiddie, DL, Schwalm, K, Dehority, WN, Harrod, KS, Kennedy, JL, Kothari, A, Gross, SM, Young, SA, Schroth, GP. Targeted Next Generation RNA Sequencing of Respiratory Viruses Produces Whole Genomes and Delivers Genetic Virulence and Epidemiologic Information. May 17, 2016, Invited Presentation, Human Pathogen Detection Summit, Daytona Beach, Florida.

Waldron J, Curry D, House S, Sikes J, Eze A, Jones SM, Kurten R, Kennedy JL. IL-33 and IL-13 receptors are upregulated in precision cut lung slices from donors with asthma during RV39 infection. J Allergy Clin Immun.  Feb 2017.  139(2): AB271. March, 2017, American Academy of Allergy, Asthma, and Immunology. Atlanta, GA.  AAAAI Atlanta, Georgia.

Kennedy JL, Hardin O, Denson J, Schwalm K, Godbold S, Crawley L, Abramo T, Stoner A, Kincaid JC, Dinwiddie D.  A Cross-sectional Study of Asthma Exacerbations in the Emergency Department:  Viral Infections and the Microbiome. J Allergy Clin Immun.  Feb 2017.  139(2): AB85. American Academy of Allergy, Asthma, and Immunology. AAP SOAI Award, Atlanta, Georgia.

Kennedy JL, Dinwiddie, DL.  “Host Pathogenic Determinants of Pediatric Respiratory Infection Severity.”  CTSA Western Consortium.  University of New Mexico.  December 2016.  Albuquerque, New Mexico.

Kennedy JL.  “Viral Infections and Asthma:  A Storied History of Incompatibility.” ACRI Research Symposium.  Jan 2017. Little Rock, Arkansas.

Li, L. 2016 Exploring the antigen-specific memory CD4 T cell response to Chlamydia female reproductive tract reinfection. 2016 AAI Annual Meeting, Seattle, Washington.

Li, L. 2017 Tissue-resident memory CD4 T cell response to Chlamydia female reproductive tract reinfection. Chlamydia Basic Research Society 2017 Meeting, Charlotte, North Carolina.

Yibo Li, Bernice Nounamo, Adrianus Boon, Jia Liu. 2016 Human SAMD9 is a poxvirus specific antiviral factor and is antagonized by myxoma virus M062 at the N-terminal domain. XXI International Poxvirus, Asfavirus and Iridovirus Conference, Strasbourg, France .

Shana Chancellor, Bernice Nounamo, Jason Liem, Martin Cannon, Jia Liu. 2016 Myxoma virus is a candidate for immunotherapeutic virotherapy against ovarian cancer. American Society for Virology, Blacksburg, Virginia.

Bernice Nounamo, Jason Liem, Yibo Li, Sarah Blair, Martin Cannon, Jia Liu. 2016 Myxoma virus sensitizes primary ovarian cancer cells to chemotherapy drugs in vitro and prolongs survival in preclinical syngeneic model of ovarian cancer. XXI International Poxvirus, Asfavirus and Iridovirus Conference, Strasbourg, France.

Davis EM, Wang K, Kauffman YH, Lai K, Goyne HE, Liu JJ. 2016 The Effects of Alterations in the Luminal Microbial Composition on Pyroptosis of Intestinal Epithelial Cells and Mucosal Inflammation DDW, Washington, DC.

Rosson TB, Siegel E, McBride R, Liu JJ. 2016  A Dedicated Inflammatory Bowel Disease (IBD) Clinic Reduced Hospitalization and Healthcare Cost at the Veterans Healthcare Center DDW, Washington, DC.

Davis EM, Hogan EA, Wang K, Kauffman YH, Lai K, Goyne HE, Weinstein RS, Liu JJ. 2016 Metabolic bone disease associated with inflammatory bowel disease is due to increased bone resorption and correlates with IL-1β activity over time. DDW, Washington, DC.

Voth, D.E. 2017. International Congress on Rickettsia and Other Intracellular Bacteria.  Defining Coxiella-Host Cell Interactions Using a Human Lung Infection Platform.  (Invited Speaker), Marseille, France.

Voth, D.E. 2017. University of Missouri Molecular Pathogenesis and Therapeutics Program.  The Living Lung:  Modeling Pulmonary Bacterial Pathogen Interactions with Humans, Columbia Missouri.

Voth, D.E. 2017. University of Texas Medical Branch Department of Pathology.  The Living Human Lung:  A Model of Coxiella burnetii-Host Interactions, Galveston, Texas.

Voth, D.E. 2016. Portland State University Department of Biological Sciences.  The Living Human Lung:  A Model of Coxiella burnetii-Host Interactions, Portland, Oregon.

Dorion, K.R., Dragan, A.L., Kurten, R.C., Smeltzer, M.S., and D.E. Voth. 2017. Characterizing a Novel Platform to Study Staphylococcus aureus Pulmonary Infection. Staphylococcal Diseases Gordon Conference, Waterville Valley, New Hampshire.

Dragan, A.L. and D.E. Voth. 2017. Characterizing Coxiella burnetii Infection of Human Lung Epithelial Cells. International Congress on Rickettsia and Other Intracellular Bacteria, Marseile, France.

Doiron, K.R. and D.E. Voth. 2017. Coxiella burnetii Subversion of the Macrophage Unfolded Protein Response. International Congress on Rickettsia and Other Intracellular Bacteria, Marseile, France.

Winchell, C.G., Graham, J.G., Colonne, P.M., Kurten, R.C., and D.E. Voth.  2016. Coxiella burnetii Manipulation of Host Autophagy and Cargo Receptors.  American Society for Rickettsiology Annual Meeting, Big Sky, Montana.

Winchell, C.G., Graham, J.G., Kurten, R.C., and D.E. Voth.  2016. Subversion of Macrophage Autophagy and Inflammatory Pathways by Coxiella burnetii.  American Association of Immunologists Annual Meeting, Seattle, Washington.

Dragan, A.L. and D.E. Voth. 2017. Characterizing Coxiella burnetii Infection of Human Lung Epithelial Cells. UAMS Student Research Day, Little Rock, Arkansas.

Doiron, K.R. and D.E. Voth. 2017. Coxiella burnetii Subversion of the Macrophage Unfolded Protein Response. UAMS Student Research Day, Little Rock, Arkansas.